Toxicology International (Formerly Indian Journal of Toxicology)

Sreemoyee Chatterjee , Madhu Kumar , Ashok Kumar

Abstract

Cancer is not a single disease but a group of complex genetic diseases of aged cells. Chemoprevention of cancer is the attempt to use natural and synthetic compounds to intervene in the early stages of cancer, before invasive disease begins. Consuming a diet rich in plant foods can provide a milieu of phytochemicals and non-nutritive plant substances that possess health-protective effects. Some phytochemicals derived in spices and herbs as well as other plants possess substantial cancer preventive properties. Thus the cancer chemo preventive potential of naturally occurring phytochemicals is of great interest because of their preventive role and as they are not perceived as “medicine”. During the course of present study Trigonella foenum graecum (L.) seed- TFGS (commonly called fenugreek) extract was given at pre-initiational, post-initiational, promotional and throughout the experiment along with 7,12-dimethylbenz [a] anthracene DMBA and 12-O-tetradecanoylphorbol-13-acetate TPA treatment in Swiss albino mice. A significant reduction of papillomas in DMBA + TPA + TFGS (400 mg/kg. body wt.) treated group was found to be effective in decreasing the rate of tumor incidence in comparison to control. Furthermore, cumulative number of papillomas, tumor yield and tumor burden were also found to be reduced. The TFGS extract treatment before DMBA and TPA application (i.e. Pre initiation) were more effective than that of treatment during, and /or after DMBA treatment, however TFGS extract treatment was most effective when treated throughout all the stages of tumorigenesis. The TFGS treatment also showed a modulatory influence on mouse hepatic antioxidant defense system (GSH and LPO level).

Keywords

Cancer, chemoprevention, DMBA, phytochemicals, TPA, Trigonella foenum graecum

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Mahaveer Suman ¹, M. C. Jain ², Jitendra Singh ¹, R. R. Meena ³, Ashok Kumar ¹, Ashutosh Mishra ¹, Prerak Bhatnagar ¹

Affiliations
1 College of Horticulture and Forestry, Jhalawar - 326023, Rajasthan, IN
2 College of Agriculture, Kota – 324001, Rajasthan,, IN
3 Krishi Vigyan Kendra, Kota (Agriculture University, Kota), Kota – 324001, Rajasthan, IN

Abstract

Abstract An investigation was carried out under the Department of Fruit Science, College of Horticulture and Forestry, Jhalawar. The experiment was conducted in the pomegranate orchard established under high density planting system at the Krishi Vigyan Kendra, Jhalawar in the near vicinity of the college during July 2018 to December 2018 and again during July 2019 to December 2019. The experiment was laid out in Factorial Randomized Block Design and experiment comprised of 27 treatment combinations consisting of plant growth regulators levels (NAA 0, 50 and 100 ppm and ethrel 0, 150 and 250 ppm) and fertigation levels (0, 75 and 100% recommended dose of fertilizers). Results revealed that maximum mean per cent increase in plant height (10.34), plant spread viz., East-West (7.01) and North-South (6.62), canopy volume (25.87) and leaf area (19.51 cm2) was recorded under F2 (fertigation 100% recommended dose of fertilizers). However, interaction effect of NAA, ethrel and fertigation were found to be relatively higher to their individual effect. In interaction effect maximum mean per cent increase in plant height (13.28), plant spread viz., East-West (8.03) and North-South (7.71), canopy volume (31.72) and leaf area (23.55 cm2) was recorded under N2E1F2 (100 ppm NAA + 150 ppm ethrel + 100% RDF through fertigation).

Keywords

Fertigation, High Density Planting, Plant Growth, Pomegranate.

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